A little more info.
I have had some success getting a USB to Serial Adapter to function properly. By that I mean I plugged it in, restarted mango, and it showed up in the list.
The device in question is a Model USOPTL4 from B & B Electronics.
So far I have attempted to use the Moxa realcom TTY driver in the following environments.
KVM/QEMU instance on Ubuntu 12.04 64bit HOST Ubuntu 12.04 32bit GUEST - This install required modification of Moxa Source Code npreal2.c[line ~759 "terminos_locked"]
KVM/QEMU instance on Ubuntu 12.04 64bit HOST Ubuntu 12.04 64bit GUEST
Ubuntu 12.04 32bit installed on HP laptop.
Ubuntu 12.04 32bit installed on Dell Dimensions 400 Desktop
Virtualbox instance on Windows 7 64bit HOST Ubuntu 12.04 32bit GUEST
Amazon Cloud using EBS Volume - Ubuntu 12.04 32bit from Ubuntu servers lists
Amazon Cloud using EBS Volume - Ubuntu 12.04 64bit from Ubuntu servers lists
I have had similar results on all of the installs. The exception being that I have not connected USB adapters to all of the virtualized installs. Some of the installs show /dev/ttyS0 in the list and some do not.